Transmission disequilibrium test (TDT) for case–control studies
نویسندگان
چکیده
منابع مشابه
Transmission disequilibrium test (TDT) when only one parent is available: the 1-TDT.
The transmission disequilibrium test (TDT) is a useful method to locate mutations linked to disease genes associated with complex diseases. TDT requires genotypes of affected individuals and their parents. Recently, Ewens and Spielman (Am J Hum Genet 1998;62:450-8) extended the TDT for use in sibships with at least one affected and one unaffected individual and devised a new test called the sib...
متن کاملSample Sizes for the Transmission Disequilibrium Tests: Tdt, S-tdt and 1-tdt
The transmission/disequilibrium test (TDT) is widely used to detect the linkage disequilibrium between a candidate locus (a marker) and a disease locus. The TDT is a family-based design and has the advantage that it is a valid test when population stratification exists. The TDT requires the marker genotypes of affected individuals and their parents. For diseases with late age of onset, it is di...
متن کاملThe impact of complex informative missingness on the validity of the transmission/disequilibrium test (TDT)
The transmission/disequilibrium test was introduced to test for linkage and association between a marker and a putative disease locus using case-parent triads. Several extensions have been proposed to accommodate incomplete triads. Some strategies assumed that parental genotypes were missing completely at random and some methods allowed informative missingness for parental genotypes. However, t...
متن کاملThe power of the transmission disequilibrium test (TDT) with both case-parent and control-parent trios.
The transmission disequilibrium test (TDT) customarily uses affected children and their parents (often case-parent trios, TDTD). Control-parent trios are necessary to guard against spurious significant results due to segregation distortion but are not generally utilized in the identification of disease susceptibility loci (DSL). Controls are often easy to recruit and the TDT can easily be exten...
متن کاملA trisomic transmission disequilibrium test.
Certain congenital disorders that are rare in the general population are quite common in individuals with trisomic conditions. For example, complete atrioventricular septal defect occurs in about 20% of individuals with Down syndrome, an approximately 500-fold increase in risk as compared to individuals without Down syndrome. Genetic variation on the chromosome involved in the trisomy may affec...
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ژورنال
عنوان ژورنال: European Journal of Human Genetics
سال: 2004
ISSN: 1018-4813,1476-5438
DOI: 10.1038/sj.ejhg.5201099